Immuno-Oncology & Immunotherapy

Immuno-oncology (I/O) has become a significant opportunity for oncology drug discovery and development. The ability to harness each person's unique immune system in a meaningful to dampen the deadly effects of tumor cells has created the explosion of precision medicine. Integrate your flow cytometry, efficacy models, imaging, biomarker, and companion diagnostics to quickly advance to the next milestone--because patients can't wait. 

  • Access over 30 different syngeneic tumor models, from both solid and disseminated origins as well as access to commercially generated humanized mouse models or client-generated models.

  • Draw on over 1000 immuno-oncology clinical study experience in the last 10 years. 

  • Partner with an oncology CRO provider who has served nearly 20.000 immuno-oncology patients in clinical trials in the last 5 years. 

Cheerful Young bald woman | Immuno-oncology precision treatment | CRO

Inmunoterapia preclínica

It is essential to meaningfully assess the immune effector cells involved in the development of a particular tumor model and those involved in mediating the anti-tumor response of individual therapeutics. For many of our models, we have growth curves available, and we continue to build our database with treatment response to agents of interest like anti-CTLA-4, anti-PDL-1, and anti-PD-1 antibodies.

In addition to testing immune-modulating agents themselves or testing other agents in combination with immune-modulators, it is important to consider the impact of radiation therapy, which is being integrated into and increasingly investigated in combination with these immuno-oncology protocols. Data showing abscopal effects of radiotherapy and immune modulators, along with direct combination anti-tumor effects, has provided proof-of-concept and is attracting further investigation of this highly utilized, clinically relevant modality in the preclinical setting.

Clinical Immuno-oncology

Hacer avances en la medicina de precisión requiere el uso de métodos novedosos para probar rápidamente y usar la terapia adecuada en el individuo correcto. Quienes trabajamos en Covance, tenemos experiencia comprobada en estudios de inmuno-oncología, incluyendo más de 100 protocolos en los últimos cinco años, llevados a cabo en 58 países, en más de 2,86 centros con más de 19,75 pacientes.

Our commitment to immuno-oncology is also evident through our support of more than 70 % of all FDA-approved companion diagnostic products. As part of a recent pivotal Phase III registration trial, our central laboratory was the sole provider of testing for PD-L1 expression, which led to a new FDA-approved diagnostic test for OPDIVO® (nivolumab). También, nuestros servicios de diagnóstico complementario, que son los mejores en su clase, respaldaron la aprobación de TagrissoTM (osimertinib) y su prueba de mutación EGFR, además del fármaco de inmunoterapia Keytruda® (pembrolizumab) y su diagnóstico complementario de PD-L1. 

Immuno-oncology Educational Resources

Whether you identify as a large pharma company with many assets in the pipeline or a biotech with an emerging portfolio, we have resources to help you at each point in your journey. Browse our clinical educational immuno-oncology resources by what best identifies your company's pipeline: